In order to best serve all populations, public health professionals must recognize that a wide range of factors impact people’s health and well-being. The factors are described as social and structural determinants of health (SDOH)?conditions in the environments in which people live, learn, work, and play. These conditions are crucial to all aspects of public health practice, from assessing the needs and strengths of populations to evaluating the impact of interventions, policies, and practices. This module is structured as a series of questions and answers that allows the user to access resources to strengthen areas of limited understanding. Are you up to the challenge?