In this month’s Log-In2Learn webinar, Dr. Renata Schiavo, PhD, MA, CCL, surveys evidence-based systems strategies for health professionals to challenge misinformation. She begins by reviewing socio-ecological models from the science of trust, emphasizing the importance of social, political and environmental factors. While acknowledging the new challenges posed by social media, which does not rely on peer-review or fact-checking processes, she reminds us that misinformation is older than the information age, going over historical reasons for mistrust such as the Tuskegee syphilis study. She defines an effective infodemic response, goes over 7 types of mis/dis-information as well as healthy information behaviors. This background leads to the paradigm shift to equity- and community-driven strategies, which Dr.Schiavo breaks down by priority and explains how to incorporate into health promotion programming.