This course outlines how to confront barriers to vaccine acceptance by creating effective communication using behavioral science, health literacy, and techniques to combat misinformation. It provides an introduction to the key tools from each of those fields, then instructs on the five-step process of developing vaccine communications. It includes case studies to show how these principles have been applied in a real-world setting. This course is appropriate for anyone communicating about vaccination, from healthcare workers in one-on-one communications to public health promotion specialists developing full communication campaigns.