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Member Research & Reports

Member Research & Reports

Vanderbilt: Team to Study Undiagnosed Congenital Diarrhea in Infants

Researchers and pediatric gastroenterologists at four institutions, including Vanderbilt University Medical Center, were recently awarded a five-year, $9.4 million federal grant to tackle undiagnosed congenital diarrheas caused by a single gene mutation.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the funding for the Pediatric Congenital Diarrhea and Enteropathy (PediCODE) Consortium and Repository, which will consist of Vanderbilt, the University of California Los Angeles Department of Pediatrics, The Hospital for Sick Kids in Toronto and Boston Children’s Hospital.

With an estimated 50 percent of all congenital diarrheas having no known etiology, PediCODE brings together a multidisciplinary group of physician-scientists with expertise in cell biology and genetic disorders. They are working to characterize the clinical and pathophysiological features of these diarrheas and develop a clinical database and biorepository of disease-specific cells, tissues and other primary patient materials.

Dr. James Goldenring, Paul W. Sanger Professor of Experiential Surgery, will serve as Vanderbilt’s principal site investigator and consortium co-principal investigator. Vanderbilt collaborators include Dr. Sari Acra, chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition; Dr. Hernan Correa of Pediatric Pathology at Children’s Hospital; Dr. Joseph Roland, research associate professor of surgery and managing director of the Digital Histology Shared Resource; and Dr. Matt Tyska, professor of cell and developmental biology.

PediCODE is funded under an RC2 grant (RC2DK118640) for high-impact, interdisciplinary science in NIDDK research areas.

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