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Faculty & Staff Honors

Faculty & Staff Honors

University at Buffalo Researcher Awarded Grant to Research Factors that Activate TLR Signaling Pathways in Sjogren’s Syndrome

Dr. Guan Yu, assistant professor of biostatistics in the University at Buffalo School of Public Health received a $232,289 award titled, “Analysis of MyD88-Mediated Immune Activation in Sjogren’s Syndrome” from the National Institute of Dental & Craniofacial Research/NIH.

Sjogren’s Syndrome is a “systemic autoimmune disease that affects the entire body. Along with symptoms of extensive dryness, other serious complications include profound fatigue, chronic pain, major organ involvement, neuropathies and lymphomas” according to the Sjogren’s Syndrome Foundation. Nearly four million Americans currently live with the disease.

“The goal of this project is to evaluate the means by which Myeloid Differentiation Factor Primary Response Protein 88 (MyD88) mediated signaling contributes to Sjogren’s syndrome and to identify specific factors that activate Toll-like receptor (TLR) signaling pathways in Sjogren’s syndrome,” stated Dr. Yu. “MyD88 is an ubiquitously expressed adaptor molecule employed by all immune cells that is required for most TLR signaling.”

Dr. Yu will work on this project along with principal investigator Dr. Jill Kramer, assistant professor of oral biology in UB’s School of Dental medicine.