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Member Research & Reports

Member Research & Reports

UAB: Using Predicted Cardiovascular Disease Risk in Conjunction with Blood Pressure to Guide Antihypertensive Medication Treatment

Dr. Paul Muntner, professor of epidemiology at the University of Alabama at Birmingham School of Public Health and Director of the UAB Hypertension Center coauthored a state-of-the-art review in the latest Journal of the American College of Cardiology.

[Photo: Dr. Paul Muntner]

Using cardiovascular disease (CVD) risk instead of or in addition to blood pressure (BP) to guide antihypertensive treatment is an active area of research. The purpose of this review is to provide an overview of studies that could inform this treatment paradigm. We review data from randomized trials on relative and absolute CVD risk reduction that can occur when antihypertensive treatment is guided by CVD risk. We also review population-level data on using CVD risk in conjunction with BP to guide antihypertensive treatment, the broad distribution in CVD risk for people with similar BP levels, and the use of CVD risk for guiding antihypertensive treatment among subgroups including older adults, young adults, and those with diabetes mellitus or chronic kidney disease. In addition, we review potential challenges in implementing antihypertensive treatment recommendations that incorporate CVD risk. In closing, we provide recommendations for using CVD risk in combination with BP to guide antihypertensive treatment.

The coauthor of this article is Dr. Paul Whelton from the Department of Epidemiology at Tulane University School of Public Health and Tropical Medicine.