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Member Research & Reports

Member Research & Reports

UAB: Severity of Hypertension Mediates the Association of Hyperuricemia With Stroke in the REGARDS Case Cohort Study

The prevalence of hyperuricemia is increasing in the U.S. and across the world. Previous studies do not widely support hyperuricemia as a risk factor for stroke and other cardiovascular diseases. This paper assessed the relationship between hyperuricemia and ischemic stroke (≈900 cases) using a large data set from the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). REGARDS is one of the largest population-based prospective cohort studies of whites and blacks in the United States, and was designed to assess geographic and racial differences in stroke mortality.

A team of researchers collaborated on this study, including Dr. George Howard and Dr. Suzanne Judd, Department of Biostatistics, Dr. Emily Levitan, Dr. Marguerite Irvin and Dr. Lisandro Colantonio, Department of Epidemiology, from the University of Alabama at Birmingham School of Public Health.

This paper is a comprehensive analysis of the relationship between serum urate and incident ischemic stroke, quantifying the role of individual comorbidities (eg, blood pressure) in mediating the effect of serum urate on stroke as well as examining differences in themain effect by race, gender, and age.

We conclude that hyperuricemia may be a risk factor for stroke. If further confirmed, the findings of the study will encourage clinicians to monitor hypertension severity while assessing the risk of stroke in individuals with high serum urate levels. Additionally, targeting this high-risk population and implementing early measures of hypertension prevention may help to reduce the risk for stroke events among patients with hyperuricemia.

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