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Member Research & Reports

Member Research & Reports

Taiwan Study Shows Children with Asthma May Benefit from Probiotics

A clinical trial supports that probiotics may have benefits on children with asthma. A Taiwan research team revealed that children who have received Lactobacillus administration for 3 months in addition to standard care had lower asthma severity and better asthma control. This study has been published in Nutrients.

Asthma has rising its prevalence for decades. The disease-related burden is getting greater worldwide. Under the microbial hypothesis, probiotics may have benefits on atopic diseases. However, these effects on children with asthma remain unclear. Professor Wei-Chu Chie of Institute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, her PhD student Dr. Chian-Feng Huang, and Dr. Huang’s clinical supervisor Dr. I-Jen Wang of the department of pediatrics, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, conducted a clinical trial and found Lactobacillus administration is beneficial to asthmatic children.

The researchers designed the double blind, prospective, randomized, placebo-controlled trial to evaluate the efficacy of Lactobacillus paracasei (LP), Lactobacillus fermentum (LF), and their combination (LP + LF) in school-age children with asthma. This study recruited a total of 160 children with asthma aged 6–18 years and evaluated the effects on the clinical severity, immune biomarkers, and quality of life. Children receiving LP, LF, and LP + LF demonstrated lower disease severity with higher children asthma control test (C-ACT) scores compared to the placebo group. Moreover, increased peak expiratory flow rate and decreased Immunoglobulin E levels were noticed in the LP + LF group.

The authors hope these results can provide health care professionals evidence of probiotics administration for childhood asthma, and furthermore, they believe the research can also inspire public health experts and influence on long-term policy making for health promotion.


Huang, C.-F.; Chie, W.-C.; Wang, I.-J. Efficacy of Lactobacillus Administration in School-Age Children with Asthma: A Randomized, Placebo-Controlled Trial. Nutrients 201810, 1678;