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Member Research & Reports

Member Research & Reports

South Carolina: Researchers Examine Antibodies Against Periodontal Microbes and Cancer Mortality

Researchers from the Department of Epidemiology and Biostatistics at the University of South Carolina Arnold School of Health, Nanjing Medical University, National Institute of Environmental Health Sciences, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development have published a study examining Serum IgG antibodies against periodontal microbes and cancer mortality. Their findings were published in JDR Clinical and Translational Research.

Previous research has linked periodontitis – a chronic inflammatory condition initiated by microorganisms – to chronic conditions such as cancer, cardiovascular disease and diabetes mellitus. With this study, the researchers investigated the associations between clusters of IgG antibodies and 19 selected periodontal microorganisms and cancer mortality.

The authors analyzed data on nearly 6,500 patients (ages 40 and older) who completed the Third National Health and Nutrition Examination Survey between 1988 and 1994 and then were follow up to death through 2011. During the mean 16 years of follow-up, 31.3 percent of the participants died, including 631 cancer-related deaths.

The researchers’ analyses revealed that antibodies against Eubacterium nodatum and Actinomyces naeslundii may be novel predictors of cancer mortality. They note that if future studies establish a causal relationship between these antibodies and cancer mortality, they could be targets to prevent possible systemic effects by raising their levels..

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