Dr. Carrie Karvonen-Gutierrez, assistant professor in the Epidemiology Department and core faculty member in the Center for Midlife Science at SPH, has been awarded a five-year NIH K01 Mentored Research Scientist Development Award.
[Photo: Dr. Carrie A. Karvonen-Gutierrez]
Dr. Karvonen-Gutierrez is studying the use of metabolomics for early detection of osteoarthritis (OA) risk.
“OA, a debilitating age-related disease associated with pain, stiffness and poor functioning, is a major risk factor for mobility disability,” Dr. Karvonen-Gutierrez says. “Although early osteoarthritic changes within the joint typically begin around 40 to 65 years of age, early detection of the disease is limited given the lack of robust and reliable OA biomarkers.”
Metabolomics, a newly evolving field, analyzes small molecules in biological specimens. Metabolomics analysis has successfully identified novel biomarkers for diagnosis, monitoring and treatment for age-related diseases such as prostate cancer, diabetes and stenosis, and autoimmune diseases such as rheumatoid arthritis, Dr. Karvonen-Gutierrez says.However, no studies to date have used metabolomics to identify biomarkers for OA or evaluated biomarkers among individuals matched for age and body size.
This K01 is funded to conduct a metabolomics analysis of OA risk within the longitudinal Michigan site of the Study of Women’s Health Across the Nation (MI-SWAN).