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Member Research & Reports

Member Research & Reports

LSU: Neighborhood Social Determinants of Triple Negative Breast Cancer

According to Dr. Richard Scribner, professor at the Louisiana State University Health Sciences Center School of Public Health, Triple Negative Breast Cancer (TNBC) is an aggressive, heterogeneous subtype of breast cancer, which is more frequently diagnosed in African American (AA) women than in European American (EA) women. Dr. Scribner and a team of LSUHSC faculty and researchers investigated the role of social determinants in racial disparities in TNBC in this study. Using multilevel statistical models, they analyzed the role of neighborhood concentrated disadvantage index (CDI), a robust measure of physical and social environment, in racial disparities in TNBC incidence, stage at diagnosis, and stage-specific survival for the study population. Controlling for age, they found that AA women had  2.21 times the incidence of TNBC incidence compared to EA women. AA women were more likely to be diagnosed at later stages and CDI was associated with more advanced stages of TNBC at diagnosis. CDI was also significantly associated with poorer stage-specific survival. Overall, their results suggest that neighborhood disadvantage contributes to racial disparities in stage at diagnosis and survival among TNBC patients, but not to disparities in incidence of the disease.

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