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Member Research & Reports

Member Research & Reports

Kentucky Cancer Registry Shows Spike in Neuroendocrine Tumors Versus SEER Data

The article “Neuroendocrine Tumor Incidence Over 18 Years: Kentucky Cancer Registry vs SEER,” published in the journal Pancreas, utilizes nearly two decades of data on neuroendocrine tumors to evaluate the prevalence of disease in Kentucky versus the US.


[Photo: Dr. Thomas Tucker (left) and Dr. Bin Huang]

NETs have a low incidence but a relatively high prevalence. Over the last three decades, NETs incidence has risen 5-fold. Greater awareness, pathological re-classification and improved diagnostics may account, at least in part, for this increase. Investigators conducted an observational study to test the hypothesis that NETs incidence in Kentucky is comparable to that reported in the National Cancer Institute Surveillance, Epidemiology, and End Results program (SEER).

Kentucky Cancer Registry (KCR) and SEER databases between 1995 and 2012 were reviewed. State and local institutional review boards approved access to KCR. Incidence data were adjusted for population and plotted. A ‘best fit’ regression analysis and ANOVA were performed using SAS with p < 0.05 considered statistically significant.

KCR recorded 5,641 individuals with newly diagnosed NETs between 1995-2012.The incidence of NETs in KCR increased from 3.8 (1995) to 10.7 (2012) per 100,000 cases, while it increased from 4.0 (1995) to 6.4 (2012) in the SEER database. The incidence rates in both KCR and SEER databases between 1995-2012 were linear with R2 values of 0.95 and 0.90, respectively. The incidence slopes were defined by the following equations: y = 0.4219x- 838 (KCR) and y = 0.1407x-277 (SEER). The difference between these incidence rates was statistically significant (p < 0.0001).

NETs incidence between 1995-2012 showed a linear increase in both KCR and SEER databases. However, the rate of increase was noted to be significantly higher in Kentucky when compared with national data. Specifically, for 2012, the incidence of NETs in Kentucky approached almost twice to that reported in SEER.

Investigators included Dr. Bin Huang, associate professor of Cancer Biostatistics, University of Kentucky College of Public Health, and director of Population-Based Cancer Research at the Kentucky Cancer Registry, and Dr. Thomas Tucker, associate professor of Epidemiology, UK College of Public Health, and associate director for cancer prevention and control, UK HealthCare Markey Cancer Center.