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Member Research & Reports

Florida International: Researchers Team up with University of Minnesota to Develop Database of DNA Adducts

Dr. Marcus S. Cooke, professor in the Department of Environmental Health Sciences at Florida International University Robert Stempel College of Public Health & Social Work, is a coinvestigator on a $164,000 grant from National Institute of Environmental Health Sciences (NIEHS) in partnership with Dr. Anthony P. DeCaprio, Department of Chemistry & Biochemistry in the College of Arts, Science and Education at FIU, and a team of researchers from the University of Minnesota, including Drs. Jingshu Guo, Peter Villalta, Scott Walmsley, and Robert Turesky. The project represents an international collaboration with multiple research institutes, and commercial vendors worldwide, the team will develop and curate a comprehensive database of DNA adduct standards.

“DNA adductomics detects both expected and unexpected adducts, and some of those unexpected ones might also be unidentified. Having an adductome database will accelerate the identification of these unexpected adducts,” said Dr. Cooke.

The targeted analysis of DNA adducts over the past 30 years has revealed that the human genome contains a wide array of DNA adducts, many of which are attributed to life-style factors, such as smoking, eating well-done cooked meats, or through oxidative stress. With the advancement of high-resolution mass spectrometry instrumentation and new scanning technologies, untargeted ’omics approaches have become available to simultaneously screen for multiple DNA adducts in a single assay. However, the development of this emerging field of DNA adductomics is hindered by the lack of a publicly available mass spectral database for DNA adduct identification and characterization.

This is Dr. Cooke’s fourth, currently active NIEHS grant.

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