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Member Research & Reports

Member Research & Reports

East Tennessee Co-Authors Article in the American Journal of Medical Sciences

Dr. Hadii Mamudu, associate professor in the Department of Health Services Management and Policy at East Tennessee State University College of Public Health, has co-authored an article in the American Journal of the Medical Sciences.  The article, Diagnostic Value of Noninvasive Computed Tomography Perfusion Imaging and Coronary Computed Tomography Angiography for Assessing Hemodynamically Significant Native Coronary Artery Lesions, assesses the diagnostic performance of computed tomography perfusion with and without computed tomography angiography in assessment of hemodynamically significant coronary artery lesions in comparison to invasive fractional flow reserve.

[Photo: Dr. Hadii Mamudu]

Co-authors include Dr. Sreenivas Veeranki, an alumnus of the Doctor of Public Health program in the College of Public Health who is currently a faculty member at the University of Texas Medical Branch, along with Dr. Timir Paul and colleagues from the East Tennessee State University Department of Internal Medicine, Division of Cardiology, of the James H. Quillen College of Medicine.

Despite major advancements in the field of cardiovascular medicine, cardiovascular events remain a major cause of mortality and morbidity worldwide.  Risk stratification is very important in managing patients with coronary artery disease.

To assess the status of the coronary vessels, noninvasive imaging can be performed either with computed tomography angiography or with computed tomography perfusion.  Computed tomography perfusion imaging can identify adequate blood flow, while computed tomography angiography visualizes the vessels themselves.   Combining the two techniques may provide a more comprehensive noninvasive evaluation of intermediate coronary artery lesion.

Until now, the gold standard test for further evaluation of an intermediate lesion has been invasive coronary angiography with fractional flow reserve measurement.  Several studies have evaluated the diagnostic accuracy of the less invasive computed tomography perfusion compared to fractional flow reserve but have been limited due to small sample size.

The results of this meta-analysis suggest that the diagnostic performance of computed tomography perfusion with computed tomography angiography in the assessment of hemodynamically significant coronary artery lesions is comparable to invasive fractional flow reserve in patients with stable coronary artery stenosis.

As the official journal of the Southern Society for Clinical Investigation, the mission of The American Journal of the Medical Sciences is to support the exchange of knowledge and information and to publish high quality clinical, basic, and education research.