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Member Research & Reports

Member Research & Reports

Biological Clock Disruptions Increase Breast Cancer Risk, UGA Study Finds

The disruption of a person’s circadian rhythm—their 24-hour biological clock—has been linked to an increased risk of breast cancer, according to new University of Georgia research. The culprit, in this study in particular, is artificial light.


[Photo: Dr. Sara Wagner Robb (left) and Ms. Chunla He]

“Exposure to artificial light leads to a significantly higher risk for developing breast cancer,” said Ms. Chunla He, a biostatistics graduate student in the UGA College of Public Health. “To decrease the use of artificial light, people should avoid working at night and implement earlier bedtimes.”

Her research, published in the International Archives of Occupational and Environmental Health, examined key studies that included risk factors for developing breast cancer.

“A large body of related research about circadian rhythms and breast cancer exists,” Ms. He said. “However, these studies are inconsistent and have a variety of limitations.”

Under the mentorship of Dr. Sara Wagner Robb, assistant professor of epidemiology in the College of Public Health, Ms. He turned to previous studies to see what the research revealed.

In addition to other relevant exposures, Ms. He examined studies on breast cancer and flight attendants, who typically work both day and night shifts. The flight attendants represented a group of workers particularly susceptible to disrupted circadian rhythms, which are heavily influenced by light.

In her analysis, Ms. He found that employment as a flight attendant was related to an increased risk of breast cancer.

“People naturally secrete the hormone melatonin, which helps to regulate the circadian rhythm,” Ms. He said. “When the sleep-wake cycle is disrupted by artificial light, melatonin secretion is adversely affected.”

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