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Member Research & Reports

Member Research & Reports

Arizona Study Finds Adherence to Cancer Prevention Guidelines is Associated With Higher Concentrations of Vitamin D

Several lifestyle factors targeted by the American Cancer Society (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines are also associated with circulating concentrations of vitamin D metabolites. This suggests that greater adherence to the ACS guidelines may be related to better vitamin D status.

[Photo: Dr. Lindsay N. Kohler]

Lead author Dr. Lindsay N. Kohler, alumna and colleagues from the University of Arizona Mel and Enid Zuckerman College of Public Health examined the relation between adherence to the ACS guidelines and circulating concentrations of 2 vitamin D metabolites, 25-hydroxycholecalciferol [25(OH)D] and 1α,25-dihydroxyvitamin D [1,25(OH)2D]. The study is published in the Jan. 27 issue of the American Society for Nutrition.

The researchers conducted cross-sectional analyses of pooled participants from the Wheat Bran Fiber (n = 503) and Ursodeoxycholic Acid (n = 854) trials. A cumulative adherence score was constructed with the use of baseline data on body size, diet, physical activity, and alcohol consumption. Continuous vitamin D metabolite concentrations and clinically relevant categories were evaluated with the use of multiple linear and logistic regression models, respectively.

The most adherent participants were more likely to be older, white, and nonsmokers than were the least adherent. A statistically significant association was observed between guideline adherence and concentrations of circulating 25(OH)D. For 1,25(OH)2D concentrations, high adherence was again significantly related to greater metabolite concentrations, with mean ± SE concentrations of 36.3 ± 1.3 pg/mL and 31.9 ± 1.0 pg/mL for high- and low-adherers, respectively. Furthermore, the odds of attaining a sufficient 25(OH)D status were 4.37 times higher for those most adherent than for those least adherent.

The authors conclude the findings demonstrate that greater adherence to the ACS guidelines is associated with higher circulating concentrations of both of 25(OH)D and 1,25(OH)2D.

Greater adherence to cancer prevention guidelines is associated with higher circulating concentrations of vitamin D metabolites in a cross-sectional analysis of pooled participants from two chemoprevention trials

The American Society for Nutrition, January 27, 2017

Lindsay N Kohler, Elizabeth A Hibler, Robin B Harris, Eyal Oren, Denise J Roe, Peter W Jurutka, and Elizabeth T Jacobs;jn.116.243352v1