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Member Research & Reports

Member Research & Reports

Arizona Study Examines Detection of Latent Tuberculosis Infection in the Border States of Nuevo Leon and Tamaulipas, Mexico

A study led by Dr. Eyal Oren, assistant professor of epidemiology from the University of Arizona Mel and Enid Zuckerman College of Public Health and colleagues examined Interferon gamma-based detection of latent tuberculosis infection in the border states of Nuevo Leon and Tamaulipas, Mexico. The study is published in the journal Frontiers in Public Health.

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[Photo: Dr. Eyal Oren]

Nearly one-third of the world’s population is infected with latent tuberculosis (LTBI). Tuberculosis (TB) rates in the border states are higher than national rates in both the U.S. and Mexico, with the border accounting for 30 percent of total registered TB cases in both countries.

However, LTBI rates in the general population in Mexican border states are unknown. In this region, LTBI is diagnosed using the tuberculin skin test (TST). New methods of detection more specific than TST have been developed, although there is currently no gold standard for LTBI detection.

The objective of the study was to demonstrate utility of the Quantiferon TB gold In-Tube (QFT-GIT) test compared with the TST to detect LTBI among border populations. This is an observational, cross-sectional study carried out in border areas of the states of Nuevo Leon and Tamaulipas, Mexico. Participants (n = 210) provided a TST and blood sample for the QFT-GIT. Kappa coefficients assessed the agreement between TST and QFT-GIT. Participant characteristics were compared using Fisher exact tests. Thirty-eight percent of participants were diagnosed with LTBI by QFT-GIT. The proportion of LTBI detected using QFT-GIT was almost double [38% (79/210)] that found by TST [19% (39/210)] (P < 0.001). Concordance between TST and QFT-GIT was low (kappa = 0.37).

The researchers recommend further studies utilizing the QFT-GIT test to detect LTBI among border populations.

Frontiers in Public Health: