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Member Research & Reports

Member Research & Reports

Arizona: Endometriosis Linked to Adverse Pregnancy Outcomes

Endometriosis is associated with increased risk for specific adverse pregnancy outcomes, including spontaneous abortion, ectopic pregnancy, and preeclampsia, according to results of a study led by Dr. Leslie V. Farland, assistant professor of epidemiology at the University of Arizona Mel and Enid Zuckerman College of Public Health and colleagues, published in Obstetrics and Gynecology on August 8.

The researchers investigated the relationship between endometriosis and adverse pregnancy outcomes. Women between ages 25 and 42 years in 1989 reported detailed information on pregnancies and reproductive health at baseline and every two years thereafter in the Nurses’ Health Study II, a cohort study. In 2009, they completed a detailed, pregnancy-focused questionnaire. A total of 196,722 pregnancies were reported.

Adverse pregnancy outcomes included spontaneous abortion, ectopic pregnancy, stillbirth, gestational diabetes mellitus, hypertensive disorders of pregnancy (preeclampsia or gestational hypertension), preterm birth, and low birth weight.

The findings show an association between laparoscopically confirmed endometriosis and several adverse pregnancy outcomes. Future research should focus on the potential biological pathways underlying these relationships to inform screening or preventive interventions.

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